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Persistent sad, anxious, or "empty" mood
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Feelings of hopelessness, pessimism
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Feelings of guilt, worthlessness, helplessness
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Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex
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Decreased energy, fatigue, being "slowed down"
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Difficulty concentrating, remembering, making decisions
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Insomnia, early-morning awakening, or oversleeping
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Appetite and/or weight loss or overeating and weight gain
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Thoughts of death or suicide; suicide attempts
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Restlessness, irritability
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Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain
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