American Speech-Language-Hearing Association

EBP Compendium: Summary of Systematic Review

National Institutes of Health
Is Hearing Loss Due to Mutations in the Connexin 26 Gene Progressive?

Gopalarao, D., Kimberling, W. J., et al. (2008).
International Journal of Audiology, 47(1), 11-20.

Indicators of Review Quality:

The review addresses a clearly focused question Yes
Criteria for inclusion of studies are provided Yes
Search strategy is described in sufficient detail for replication No
Included studies are assessed for study quality No
Quality assessments are reproducible N/A

Description: This is a meta-analysis of studies investigating mutations in the connexin 26 gene as a cause of progressive hearing loss in individuals.

Question(s) Addressed:

Question not specifically stated.

Population: Not further specified

Intervention/Assessment: Not applicable

Number of Studies Included: 8

Years Included: Not stated.

Findings:

Conclusions:

"[Persons with this genetic mutation] who have residual hearing should be monitored with repeat audiological evaluations in the same meticulous manner as other patients with sensorineural hearing loss" (p. 19).

Keywords: Congenital Disorders, Hearing Loss

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Added to Compendium: January 2012

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