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EBP Compendium: Summary of Systematic Review

Intratympanic Gentamicin for Meniere's Disease: A Meta-Analysis

Cohen-Kerem, R., Kisilevsky, V., et al. (2004).
Laryngoscope, 114(12), 2085-2091.

Indicators of Review Quality:

The review addresses a clearly focused question No
Criteria for inclusion of studies are provided Yes
Search strategy is described in sufficient detail for replication Yes
Included studies are assessed for study quality Yes
Quality assessments are reproducible Yes

Description: This is a systematic review and meta-analysis of clinical trials concerning the effects of an intratympanic gentamicin regimen for patients with Ménière's disease. Although the review does not specifically address audiological management, it examines ototoxic effects of medication.

Question(s) Addressed:

Question not specifically stated. 

Population: Patients diagnosed as having definitive Ménière's disease according to the American Academy of Otolaryngology Head and Neck Surgery (AAO-HNS) guidelines

Intervention/Assessment: Intratympanic gentamicin treatment regimen

Number of Studies Included: 15

Years Included: 1985 – 2003





  • Treatment
    • Hearing
      • Gentamicin appears to be effective for the treatment of vertigo in individuals with Ménière's disease. Treatment did not appear to cause major cochleototoxicy or ototoxity. "However the safety of this route of administration with respect to the patient's hearing has not yet been sufficiently established" (p. 2090). 

Keywords: Ménière's Disease, Ototoxicity

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Added to Compendium: January 2012

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