EBP Compendium: Summary of Systematic Review
Evidence Behind the WHO Guidelines: Hospital Care for Children: What Is the Evidence of Safety of Gentamicin Use in Children?
McGlone, A., & Cranswick, N.
(2008).
Journal of Tropical Pediatrics, 54(5), 291-293.
Indicators of Review Quality:
|
The review addresses a clearly focused question
| Yes* |
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Criteria for inclusion of studies are provided
| Yes |
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Search strategy is described in sufficient detail for replication
| No |
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Included studies are assessed for study quality
| No |
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Quality assessments are reproducible
| N/A |
Description: This is a systematic review of randomized controlled trials investigating the safety of gentamincin use on children’s hearing.
Question(s) Addressed:
What is the evidence of safety, in terms of ototoxicity, of gentamicin use in children?
Population: Children (not further specified).
Intervention/Assessment: Gentamicin treatment
Number of Studies Included: 14, 6 of which were relevant to the ototoxicity question.
Years Included: Not stated
Findings:
Conclusions:
"Based on the evidence available, short-term gentamicin administration at the recommended doses is an appropriate antibiotic, even without serum gentamicin level monitoring." (p. 292)
Keywords: Ototoxicity
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Added to Compendium: December 2011