EBP Compendium: Summary of Systematic Review
Evidence Behind the WHO Guidelines: Hospital Care for Children: What Is the Evidence of Safety of Gentamicin Use in Children?
McGlone, A., & Cranswick, N.
Journal of Tropical Pediatrics, 54(5), 291-293.
Indicators of Review Quality:
The review addresses a clearly focused question
Criteria for inclusion of studies are provided
Search strategy is described in sufficient detail for replication
Included studies are assessed for study quality
Quality assessments are reproducible
Description: This is a systematic review of randomized controlled trials investigating the safety of gentamincin use on children’s hearing.
What is the evidence of safety, in terms of ototoxicity, of gentamicin use in children?
Population: Children (not further specified).
Intervention/Assessment: Gentamicin treatment
Number of Studies Included: 14, 6 of which were relevant to the ototoxicity question.
Years Included: Not stated
"Based on the evidence available, short-term gentamicin administration at the recommended doses is an appropriate antibiotic, even without serum gentamicin level monitoring." (p. 292)
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Added to Compendium: December 2011