EBP Compendium: Summary of Systematic Review
National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Dependence of Hearing Changes on the Dose of Intratympanically Applied Gentamicin: A Meta-Analysis Using Mathematical Simulations of Clinical Drug Delivery Protocols
Salt, A. N., Gill, R. M., et al.
(2008).
Laryngoscope, 118(10), 1793-1800.
Indicators of Review Quality:
|
The review addresses a clearly focused question
| No |
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Criteria for inclusion of studies are provided
| Yes |
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Search strategy is described in sufficient detail for replication
| No |
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Included studies are assessed for study quality
| No |
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Quality assessments are reproducible
| N/A |
Description: This is a meta-analysis of studies investigating safe dosages of intratympanic gentamicin that can be used in individuals being treated for Meniere's disease without resulting ototoxicicity.
Question(s) Addressed:
Question not specifically stated.
Population: Not stated
Intervention/Assessment: Not applicable.
Number of Studies Included: 19
Years Included: Not further specified.
Findings:
Conclusions:
"...[T]here appears no logical rationale for rapidly repeated or continuous applications of gentamicin in the treatment of Meniere's disease." (p.1798)
Keywords: Ototoxicity, Hearing Loss
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Added to Compendium: December 2011