EBP Compendium: Summary of Systematic Review
The Cochrane Collaboration
Antidepressants for Patients with Tinnitus
Baldo, P., Doree, C., et al.
Cochrane Database of Systematic Reviews (4).
Indicators of Review Quality:
The review addresses a clearly focused question
Criteria for inclusion of studies are provided
Search strategy is described in sufficient detail for replication
Included studies are assessed for study quality
Quality assessments are reproducible
Description: This is a systematic review of randomized controlled trials investing the use of antidepressant therapeutic drugs to treat the symptoms of tinnitus.
In individuals experiencing tinnitus:
Is antidepressant pharmaceutical therapy effective at improving tinnitus severity and disability?
Is antidepressant pharmaceutical therapy effective at improving tinnitus perception, loudness, or intensity?
Is antidepressant pharmaceutical therapy effective at improving or changing depressive symptoms?
Is antidepressant pharmaceutical therapy effective at improving or changing global well-being?
Population: “Patients diagnosed with tinnitus in whom underlying pathologic conditions such as Ménière’s disease, vestibular schwannomas, cervical spine lesions, or otosclerosis have been excluded or not detected” (p. 6).
Intervention/Assessment: Antidepressant therapy including: tricyclic antidepressant agents and SSRI antidepressant agents.
Number of Studies Included: 5
Years Included: Through March 2006
- There is no evidence that tricyclic antidepressants are effective or ineffective in the management of tinnitus.
- A solitary well conducted trial or a selective serotonin reuptake inhibitor showed no benefit for most outcome measures.
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Added to Compendium: December 2011