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EBP Compendium: Summary of Systematic Review

Evidence Behind the WHO Guidelines: Hospital Care for Children: What Is the Evidence of Safety of Gentamicin Use in Children?

McGlone, A., & Cranswick, N. (2008).
Journal of Tropical Pediatrics, 54(5), 291-293.

Indicators of Review Quality:

The review addresses a clearly focused question Yes*
Criteria for inclusion of studies are provided Yes
Search strategy is described in sufficient detail for replication No
Included studies are assessed for study quality No
Quality assessments are reproducible N/A

Description: This is a systematic review of randomized controlled trials investigating the safety of gentamincin use on children’s hearing.

Question(s) Addressed:

What is the evidence of safety, in terms of ototoxicity, of gentamicin use in children?

Population: Children (not further specified).

Intervention/Assessment: Gentamicin treatment

Number of Studies Included: 14, 6 of which were relevant to the ototoxicity question.

Years Included: Not stated



"Based on the evidence available, short-term gentamicin administration at the recommended doses is an appropriate antibiotic, even without serum gentamicin level monitoring." (p. 292)

Keywords: Ototoxicity

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Added to Compendium: December 2011

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